Linstedt Lab Web Page: Under Development

LINSTEDT LAB PUBLICATIONS

DEPT OF BIOLOGICAL SCIENCES

CARNEGIE MELLON UNIVERSITY

4400 5^TH AVENUE

PITTSBURGH, PA 15213

· Tewari R, Jarvela T, Linstedt AD. (2014) Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin. Mol Biol Cell. Jul 30. pii: mbc.E14-05-1003.

Jarvela, T. and Linstedt, A.D. (2014). “The application of KillerRed for acute protein inactivation in living cells.” Current Protocols, 69:12.35.1-12.35.10. PMID: 24984963
Veenendaal, T., Jarvela, T., Grieve1, A., van Es, J., Linstedt, A.D. and Rabouille, C. (2014). GRASP65 controls the cis Golgi integrity in vivo. Biol. Open, 3(6):431-43. PMID: 24795147
Heinrich,F., Nanda, H., Zan, GH., Bachert, C., Lösche, M. and Linstedt, A.D. (2014). “Myristoylation Restricts Orientation of the GRASP domain on Membranes and Promotes Membrane Tethering”, J Biol Chem. 289:9683-9691. PMID: 24505136.

· Guo, Y. and Linstedt, A.D. (2014). “Binding of the vesicle docking protein p115 to the GTPase Rab1b regulates membrane recruitment of the COPI vesicle coat”, Cell Logist, 3:e27687, doi: 10.4161/cl.27687.

Jarvela, T. and Linstedt, A.D. (2014). “Isoform-specific tethering links the Golgi ribbon to maintain compartmentalization”, Mol Biol Cell, 25:133-144. PMID: 24227884.

Mukhopadhyay, S., Redler, B, and Linstedt, A.D. (2013). Shiga toxin binding site for host cell receptor GPP130 reveals unexpected divergence in toxin trafficking mechanisms, MBoC, 24:2311-8 PMID 23761068.
Mukhopadhyay, S. and Linstedt, A.D. (2013). Retrograde trafficking of AB5 toxins: mechanisms to therapeutics, J Mol Med, 91:1131-1141. PMID: 23665994.
Bachert, C. and Linstedt, A.D. (2013). A Sensor of Protein O-Glycosylation Based on Sequential Processing in the Golgi apparatus, Traffic 14(1):47-56. PMID: 23046148

Yadav, S. Puthenveedu, M.A., and Linstedt, A.D. (2012) Golgin-160 recruits the dynein motor to position the Golgi apparatus, Dev. Cell 23:153-165. PMID: 22814606
Truschel, S.T., Zhang, M., Bachert, C., Macbeth, M. and Linstedt, A.D. (2012). Allosteric regulation of GRASP-dependent Golgi membrane tethering by mitotic phosphorylation, J Biol Chem., 287:19870-5. PMID: 22523075
Jarvela, T. and Linstedt, A.D. (2012). Golgi GRASPs: Moonlighting membrane tethers, Cell Health and Cytoskeleton, 2012: 37-47.
Jarvela, T. and Linstedt, A.D. (2012). Irradiation-induced protein inactivation reveals Golgi enzyme cycling to cell periphery, J. Cell Sci., 125:973-980.
Mukhopadhyay, S. and Linstedt, A.D. (2012). Manganese blocks intracellular trafficking of Shiga Toxin and protects against Shiga-induced death, Science 335:332-335. PMID: 22267811

Truschel, S.T., Sengupta, D., Foote, A., Heroux, A., Macbeth, M. and Linstedt, A.D. (2011) Structure of the membrane tethering GRASP domain reveals a unique PDZ ligand interaction that mediates Golgi biogenesis, J Biol Chem. 2011 Apr 22. [Epub ahead of print] PMID: 21515684
Sengupta, D. and Linstedt, A.D. (2011). Control of organelle size: the Golgi apparatus, Annual Review of Cell and Devel., 27:57-77. PMID: 21639798.
Yadav, S. and Linstedt, A.D. (2011). Golgi positioning. Cold Spring Harb Perspect Biol, 3(5): ePub, PMID: 21504874.
Mukhopadhyay, S. and Linstedt, A.D. (2011). Identification of a gain of function mutation in a Golgi P-type ATPase: implications for Mn2+ homeostasis and detoxification, Proc. Natl. Acad. Sci. USA, 108(2):858-63. PMID: 21187401.

Sengupta, D. and Linstedt, A.D. (2010). Mitotic inhibition of GRASP65 organelle tethering involves Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand. J Biol Chem. J Biol Chem. 285: 39994-40003.
Bachert, C. and Linstedt, A.D. (2010). Dual anchoring of the GRASP membrane tether promotes trans pairing. J Biol Chem. 285: 16294-16301.
Mukhopadhyay, S., Bachert, C., Smith, D. and Linstedt, A.D. (2010). Manganese-induced trafficking and turnover of the cis Golgi glycoprotein GPP130. Mol. Biol. of the Cell, 21: 1282-1292.
Gong, H., Guo, Y., Linstedt A.D. and Schwartz, R. (2010). Discrete, continuous and stochastic models of protein sorting in the Golgi. Phys Rev E, 81:011914.

S. Emr, B.S. Glick, A.D. Linstedt, J. Lippincott-Schwartz, A. Luini, V. Malhotra, B.J. Marsh, A. Nakano, S.R. Pfeffer, C. Rabouille, J.E. Rothman, G. Warren, and F.T. Wieland (2009). Journeys through the Golgi—taking stock in a new era. J. Cell Biol. 187: 449-53.
Sengupta, D., Truschel, S., Bachert, C. and Linstedt, A.D. (2009). Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network. J. Cell Biol. 186:51-55.
Srinivasa, G., Fickus, M.C, Guo, Y., Linstedt A.D. and Kovačević J. (2009). Active mask segmentation of fluorescence microscope images. IEEE Trans Image Process. 18(8):1817-29.
Yadav, S., Puri, S., and Linstedt, A.D. (2009). A Primary Role for Golgi Positioning in Directed Secretion, Cell Polarity and Wound Healing. Mol. Biol. of the Cell 20:1728-1736.

Gong, H. Sengupta, D., Linstedt A.D. and Schwartz, R. (2008). Simulated de novo assembly of Golgi compartments by selective cargo capture during vesicle budding and targeted vesicle fusion. Biophys. J., 95: 1674–1688.
Feinstein, NT, and Linstedt, A.D. (2008). GRASP55 regulates Golgi ribbon formation. Mol. Biol. of the Cell, 19:2696–2707.
Guo, Y., Punj, V. Sengupta, D. and Linstedt, A.D. (2008). Coat-tether interaction in Golgi organization. Mol. Biol. of the Cell, 19, 2830–2843.
Srinivasa, G., Fickus, M., Gonzalez-Rivero, Hsieh S., Guo, Y., Linstedt, A.D. and Kovacevic, J. (2008). Active-mask segmentation for the cell-volume computation and Golgi-body segmentation of HeLa cell images. Proc. IEEE Intl. Symp. Biomed. Imaging, Paris, France, May 2008, pp. 348-351.

Bachert, C., Fimmel, C.J., and Linstedt, A.D. (2007). Furin cleavage of cis-Golgi protein GP73 produces marker for liver disease. Traffic 8:1415-23.
Feinstein, T. and Linstedt, A.D. (2007). Mitogen-activated Protein Kinase Kinase-dependent Golgi Unlinking Occurs in G2 phase and Promotes the G2/M Cell Cycle Transition. Mol. Biol. of the Cell, 18:594-604.
Guo, Y. and Linstedt, A.D. (2006). COPII-Golgi Protein Interactions Regulate COPII Coat Assembly and Golgi size. J. Cell Biol. 174:53-63.
Puthenveedu, M.A., Bachert, C., Puri, S., Lanni, F. and Linstedt, A.D. (2006). GM130 and GRASP65-dependent lateral cisternal fusion confers uniform Golgi enzyme distribution. Nature Cell Bio., 8: 238-248.

Puthenveedu, M.A., Linstedt, A.D. (2005) Subcompartmentalizing the Golgi Apparatus, Curr. Opin. Cell Bio. 17: 369–375.
Natarajan, R. and Linstedt, A.D. (2004). A cycling cis Golgi protein mediates endosome-to-Golgi traffic. Mol. Biol. of the Cell 15: 4798–4806.
Linstedt, A.D. (2004). Positioning the Golgi Apparatus. Cell 118: 271-272.
Puthenveedu, M.A., and Linstedt, A.D. (2004). Gene replacement reveals that p115/SNARE interactions are essential for Golgi biogenesis. Proc. Natl. Acad. Sci. USA 101: 1253-1256 (direct track II submission).
Puri, S., Telfer, H., Velliste, M., Murphy, R., and Linstedt, A.D. (2004). Dispersal of Golgi matrix proteins during mitotic Golgi disassembly. J. Cell Sci. 117:451-456.
Puri, S. and Linstedt, A.D. (2003). Capacity of the Golgi Apparatus for Biogenesis from the Endoplasmic Reticulum. Mol. Biol. of the Cell 14:5011-5018.
Puthenveedu, M.A., Weisz, O.A. Linstedt, A.D. (2003). Basolateral cycling mediated by a lumenal domain targeting determinant. Mol. Biol. of the Cell 14:1801-1807.

Puri, S., Bachert, C., Fimmel, C.J., and Linstedt, A.D. (2002). Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption. Traffic 3:641-653.
Puthenveedu, M.A., and Linstedt, A.D. (2001). In search of an essential step during mitotic Golgi disassembly and inheritance. Exp. Cell. Res. 271: 22-27.
Jesch, S.A., Mehta, A.J, Velliste, M., Murphy, R., and Linstedt, A.D. (2001). Mitotic Golgi is in a dynamic equilibrium between clustered and free vesicles, that are independent of the ER. Traffic 2:873-884.
Puthenveedu, M.A., and Linstedt, A.D. (2001). Evidence that Golgi structure depends on a p115 activity that is independent of the vesicle tether components giantin and GM130. J. Cell Biol. 155: 227-237.
Bachert, C., Lee, T.H., and Linstedt, A.D. (2001). Lumenal endosomal and Golgi-retrieval determinants involved in pH-sensitive targeting of an early Golgi protein. Mol. Biol. of the Cell 12: 3152-3160.
Jesch, S.A., Lewis, T.S., Ahn, N.G., and Linstedt, A.D. (2001). Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen activated protein kinase ERK2. Mol. Biol. of the Cell 12:1811-1817.

Lee, T.H., and Linstedt, A.D. (2000) Potential role for protein kinases in regulation of bidirectional endoplasmic reticulum-to-Golgi transport revealed by protein kinase inhibitor H89. Mol. Biol. of the Cell 11: 2577-2590.
Linstedt, A.D., Jesch, S.A., Mehta, A, Lee, T.H., Garcia-Mata, R., Nelson, D.S., and Sztul, E. (2000). Binding relationships of membrane tethering components: the giantin N-terminus and the GM130 N-terminus compete for binding to the p115 C-terminus. J. Biol. Chem. 275(14), 10196-10201.
Linstedt, A. D., and Hauri, H.-P. (1999). Giantin, in Guidebook to the Cytoskeletal and Motor Proteinsî eds. Kreis, T. and Vale R., Oxford Univ. Press.
Linstedt, A. D. (1999). Golgi complex: Stacking the cisternae. Current Biology 9, R897-R898.
Lee, T.H., and Linstedt, A. D. (1999). Osmotically induced cell volume changes alter anterograde and retrograde transport, organelle structure, and COPI membrane dissociation. Mol. Biol. of the Cell. 10, 1445-1456.
Jesch, S.A., and Linstedt, A.D. (1998). The Golgi and endoplasmic reticulum remain independent during mitosis in HeLa cells. Mol. Biol. of the Cell. 9, 623-635.
Linstedt, A. D., Mehta, A., Suhan, J., Reggio, H., and H. -P. Hauri. (1997). Sequence and overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golgi membrane protein. Mol. Biol. of the Cell 8, 1073-1087.