Effect of Anti-PCP Mab on Rat Movement

The left graph shows rat movement as a function of time (min) after injection of PCP^* (3mg/kg PCP). Approximately 20 minutes after receiving PCP the rats become very agitated and remain so for the next hour.

The right graph shows how injection of one equivalent of anti-PCP antibody prevents the effects of PCP. The antibody is injected 30 minutes after the PCP injection and rapidly reverses the effects of PCP.

^*Long arrows indicate injection of PCP. Shorter arrows indicate injection of either saline (left graph) or antibody (right graph). Saline is essentially salt water.