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The Fos-Jun, and NFAT DNA-Binding Domains Complexed to a Specific Site. The Fos-Jun heterodimer is a human transcriptional activator (AP-1) that binds to DNA in many promoter regions. NFAT (nuclear factor of activated T cells) activates transcription at several promoters involved with immune system induction. At the interleukin-2 promoter, all three proteins bind cooperatively to stimulate transcription. This model shows the structure of that complex. The DNA, 20 bp of IL-2 regulatory region DNA, is shown as Sticks, colored green. The bZIP proteins, Fos (red) and Jun (yellow), are shown as Cartoons. (See Campbell, Fig. 10.29 for a picture of another Fos-Jun DNA complex.) NFAT is shown as Cartoons, colored Structure.
The first three"Highlight" buttons display DNA backbone and base-specific interactions. The amino acids that participate in DNA recognition are labeled (one-letter code) and shown Ball & Stick, colored CPK. The other protein residues are displayed as Backbone, colored as described above. DNA groups within 4 Å of the highlighted amino acids are colored CPK. This structure is described in Chen, L., Glover, J. N., Hogan, P. G., Rao, A., Harrison, S. C. (1998) "Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature 392: 42. PubMed Abstract. |
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