Example
I: Tapping Mode AFM Helps to Answer
Questions about Protein-DNA Interactions
(Binding
of Ku
and DNA-PK
to DNA)
VD-J recombination –
cutting and pasting DNA
Michael Lieber, University
of Southern California School of Medicine
The two major proteins involved in VD-J recombination are Ku and DNA-PK
Questions:
What are the DNA- binding modes of Ku and DNA-PK?
Can DNA-PK bind to DNA in the absence of Ku?