Biochemistry I: Glyceraldehyde-3-phosphate Dehydrogenase


Highlights:
   NAD+ binding   
   Catalytic Region      
  1. SH group of Cys is activated by His
  2. SH attacks CO, H+e- are transfered to NAD
  3. Thio-ester intermediate.
  4. Thio-ester attacted by Pi.
  Glyceraldehyde-3-phosphate dehydrogenase (1A7K.pdb) converts glyceraldehyde-3-phosphate to 1,3-bisphospholycerate. The protein is a tetramer; only one subunit is shown here. Each subunit is comprised of two-domains, as highlighted above.

The starting Display is Cartoons; the Color is Group.
The NAD+ cofactor is Spacefill colored CPK.
The amino and carboxyl termini of the protein are labeled.

Nov, 2018