While the focus of this course is to analyze membrane/protein traffic along both the biosynthetic and endocyctic pathways, our general goal is to teach students how to read and interpret the literature. In particular, we emphasize the conclusions and discuss their validity. The course is updated each year to include topics in which new and interesting developments have occurred. Emphasis is placed on how membrane traffic is regulater and where applicable how it is disrupted or subverted during disease processes. The course is of general interest to students, fellows, and faculty interested in cell biology, immunology, neurobiology, pharmacology, and virology.