This course presents both the theoretical underpinnings of computational methods used in modern molecular biology and practical training in use of these methods. It is intended for students without computer programming experience. Topics included are accessing Internet molecular biology resources, restriction enzyme analysis, finding protein coding regions (open reading frames), sequence alignment, homology searching, finding sequence features (e.g., promoters), and elementary protein structure prediction. Course work consists primarily of homework assignments making use of software packages for these applications. Students may only use one of the following for credit, 03-310, 03-311, 03-510 or 03-710.